Topoisomerase Protein Sequence Searches:
Sequence Analysis:
You may click on the following links for quick access to informative abstracts about topoisomerase (search term in quotes) provided by NIH PubMedline (ncbi genetics subset):
Evolution of Topo
The gene organization has been determined for an 8-kb portion of the Streptomyces coelicolor chromosome close to the origin of DNA replication (oriC). revealed the presence of five open reading frames (ORFs) oriented in the same direction The deduced products of three of the ORFs have been identified as the S. coelicolor homologs of RecF, GyrB and GyrA. The recF gene is flanked by two ORFs, one of which encodes a protein with significant similarity to 6-phosphogluconate dehydrogenases (6PGDH) Gene organization in the dnaA-gyrA region of the Streptomyces coelicolor chromosome. Calcutt MJ Department of Biochemistry, University of Missouri-Columbia 65212. Gene 151: 23-8 (1994) medline